The effects of orally given high rate carbohydrate on some pathogens that play an important role in etiology of the diarrhea in calves

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This study was carried out on 30 adult calves which completed their rumen development aged from three to six months old in the public held. Twenty calves received totally 1500 ml of propylene glycol per day 3-5 times/day, assigned as study group, while 10 calves that were found to be clinically healthy and didn’t receive any additional treatments served as control group. Clinical, stool, hematological and blood biochemical examinations were performed in all the animals. At the end of the study; it had been found that propylene glycol caused mild diarrhea (15%) and some slightly respiratory system problems (10%), decreased the number of calves which showed fecal-pathogenic agents in their feces, and didn’t cause significant problems in the liver. Consequently; it was determined that a glucose precursor propylene glycol could be used safely in adult calves, and it might help to reduce fecal contamination to neonates by decreasing the number of fecal pathogens, besides increased productivity.  

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ELITOK, Bulent. The effects of orally given high rate carbohydrate on some pathogens that play an important role in etiology of the diarrhea in calves. Stiinta agricola, [S.l.], n. 1, p. 112-118, july 2018. ISSN 2587-3202. Available at: <>. Date accessed: 21 feb. 2019.
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1. BARTELS, C.J.M., HOLZHAUER, M., JORRITSMA, R., SWART, W.A.J.M., LAM, T.J.G.M. (2010). Prevalence, prediction and risk factors of enteropathogens in normal and non-normal faeces of young Dutch dairy calves. In: Preventive Veterinary Medicine, vol. 93(2-3), pp. 162- 169. ISSN 0167-5877.
2. BENDALI, F., BICHET, H., SCHELCHER, F., SANAA, M. (1999). Pattern of diarrhoea in newborn beef calves in south-west France. In: Veterinary Research, vol. 30(1), pp. 6-74. ISSN 1993-5412.
3. BJERRE-HARPOTH, V., STORM, A.C., VESTERGAARD, M., LARSEN, M., LARSEN, T. (2016). Effect of postpartum propylene glycol allocation to over-conditioned Holstein cows on concentrations of milk metabolites. In: Journal of Dairy Research, vol. 83(2), pp. 156-64. ISSN 1469-7629.
4. CHO, YI., YOON, KJ. (2014). An overview of calf diarrhea - infectious etiology, diagnosis, and intervention. In: Journal of Veterinary Science, vol. 15(1), pp. 1-17. DOI 10.4142/jvs.2014.15.1.1
5. DEFRAIN, J.M., HIPPEN, A.R., KALSCHEUR, K.F., JARDON, P.W. (2004). Feeding glycerol to transition dairy cows, Effects on blood metabolites and lactation performance. In: Journal of Dairy Science, vol. 87, pp. 4195-4206. ISSN 0022-0302.
6. EMERY, R.S., BURG, N., BROWN, L.D., BLANK, G.N. (1964). Detection, occurrence and prophylactic treatment of borderline ketosis with propylene glycol feeding. In: Journal of Dairy Science, vol. 47, pp. 10741079. ISSN 0022-0302.
7. FAGAN, J.G., DWYER, P.J., QUINLAN, J.G. (1995). Factors that may affect the occurrence of enterop athogens in the feces of diarrhoeic calves in Ireland. In: Irish Veterinary Journal, vol. 48, pp. 17-21. ISSN 2046-0481.
8. FIUME, M.M., BERGFELD, W.F., BELSITO, D.V., HILL, R.A., KLAASSEN, C.D., LIEBLER, D., MARKS, J,G., SHANK, R.C., SLAGA, T.J., SNYDER, P.W., ANDERSEN, F.A. (2012). Safety assessment of propylene glycol, tripropylene glycol, and PPGs as used in cosmetics. In: International Journal of Toxicology, vol. 31(5), pp. 245-260. ISSN 1091-5818.
9. FRANK, N.A., KANEENE, J.B. (1993). Management risk factors associated with calf diarrhea in Michigan dairy herds. In: Journal of Dairy Science, vol. 76, pp. 1313-1323. ISSN 0022-0302.
10. GOHARY, K., OVERTON, M.W., Von MASSOW, M., LEBLANC, S.J., LISSEMORE, K.D., DUFFIELD, T.F. (2016). Economic value of ionophores and propylene glycol to prevent disease and treat ketosis in Canada. In: Canadian veterinary journal, vol. 57(7), pp. 733- 740. ISSN 0008-5286.
11. GORDON, J.L., LEBLANC, S.J., KELTON, D.F., HERDT, T.H., NEUDER, L., DUFFIELD, T.F. (2017). Randomized clinical field trial on the effects of butaphosphan-cyanocobalamin and propylene glycol on ketosis resolution and milk production. In: Journal of Dairy Science, vol. 100(5), pp. 3912-3921. ISSN 0022-0302.
12. HAMMER, H.F., SANTA ANA, C.A., SCHILLER, L.R., FORDTRAN, J.S. (1989). Studies of osmotic diarrhea induced in normal subjects by ingestion of polyethylene glycol and lactulose. In: Journal of Clinical Investigation, vol. 84(4), pp. 1056-1062. ISSN 0021-9738.
13. HENDRICKSON, K. (2017). Properties of Propylene Glycol [accessed: 30 Aug. 2017]. Avalable: www.
14. IVANY, J.M., ANDERSON, D.E. (2001). Propylene glycol toxicosis in a llama. In: Journal of the American Veterinary Medical Association, vol. 218, pp. 243-244. ISSN 0003-1488.
15. IZZO, M.M., KIRKLAND, P.D., MOHLER, V.L., PERKINS, N.R., GUNN, A.A., HOUSE, J.K. (2011). Prevalence of major enteric pathogens in Australian dairy calves with diarrhoea. In: Australian Veterinary Journal, vol. 89, pp. 167-173. DOI 10.1111/j.1751-0813.2011.00692.x.
16. JANKE, B.H. (1989). Protecting calves from diarrhea. In: Veterinary Medicine, vol. 84, pp. 803- 811.
17. KHAW, M., CLAIRE, B., PANOSIAN, C.B. (1995). Human Antiprotozoal Therapy, Past, Present, and Future. In: Clinical Microbiology Reviews, vol. 8(3), pp. 427-439. ISSN 0893-8512.
18. McCLANAHAN, S., HUNTER, J., MURPHY, M., VALBERG, S. (1998). Propylene glycol toxicosis in a mare. In: Veterinary and Human Toxicology, vol. 40, pp. 294-296. ISSN 0145-6296.
19. MUNDAY, R., MANNS, E. (1994). Comparative toxicity of prop(en)yl disulfides derived from Alliaceae, Possible involvement of 1-propenyl disulfides in onion-induced hemolytic anemia. In: Journal of Agricultural and Food Chemistry, vol. 42(4), pp. 959-962. DOI 10.1021/jf00040a023
20. NALAWADE, T.M., BHAT, K., SOGI, S.H.P. (2015). Bactericidal activity of propylene glycol, glycerine, polyethylene glycol 400, and polyethylene glycol 1000 against selected microorganisms. In: Journal of International Society of Preventive and Community Dentistry, vol. 5(2), pp. 114-119. DOI 10.4103/2231-0762.155736.
21. NIELSEN, N.I., INGVARTSEN, K.L. (2004). Propylene glycol for dairy cows. A review of the metabolism of propylene glycol and its effects on physiological parameters, feed intake, milk production and risk of ketosis. In: Animal Feed Science and Technology, vol. 115(3-4), pp. 191- 213. DOI 10.1016/j.anifeedsci.2004.03.008
22. OLSSON, S.O., VIRING, S., EMANUELSON, U., JACOBSSON, S.O. (1993). Calf diseases and mortality in Swedish dairy herds. In: Acta veterinaria Scandinavica, vol. 34(3), pp. 263-269. ISSN 0044-605X.
23. PEREZ, E., NOORDHUIZEN, J.P.T.M., Van WUIJKHUISE, L.A., STASSEN, E.N. (1990). Management factors related to calf morbidity and mortality rates. In: Livestock Production Science, vol. 25(1-2), pp. 79-93. ISSN 0301-6226.
24. RABOISSON, D., MOUNIE, M., MAIGNE, E. (2014). Diseases, reproductive performance, and changes in milk production associated with subclinical ketosis in dairy cows, a meta-analysis and review. In: Journal of Dairy Science, vol. 97(12), pp. 7547-7563. ISSN 0022-0302.
25. ROBINSON, E., SPRAYBERRY, K.A. (2009). Current Therapy in Equine Medicine. 6th ed. Elsevier Health Sciences, USA. 1104 p. ISBN 9781416054757.
26. SABBIONI, A., SUPERCHI, P.BONOMI, A., TAGLIETTI, P. et al. (1999). The use of propylene glycol in veal calf feeding. In: ASPA Congress, vol. 13, pp. 351-353
27. SVENSSON, C., LUNDBORG, K., EMANUELSON, U., OLSSON, S.O. (2003). Morbidity in Swedish dairy calves from birth to 90 days of age and individual calf-level risk factors for infectious diseases. In: Preventive Veterinary Medicine, vol. 58(3-4), pp. 179- 197. ISSN 0167-5877.
28. THORGEIRSDOTTIR, T.O., THORMAR, H., KRISTMUNDSDOTTIR, T. (2003). Effects of polysorbates on antiviral and antibacterial activity of monoglyceride in pharmaceutical formulations. In: Pharmazie, vol. 58(4), pp. 286-287. ISSN 0031-7144.
29. TRABUE, S., SCOGGIN, K., TJANDRAKUSUMA, S., RASMUSSEN, M.A., REILLY, P.J. (2007). Ruminal Fermentation of Propylene Glycol and Glycerol. In: Journal of Agricultural and Food Chemistry, vol. 55(17), pp. 7043−7051. DOI 10.1021/jf071076i
30. UHDE, F.L., KAUFMANN, T., SAGER, H., ALBINI, S., ZANONI, R., SCHELUNG, E., MEYLAN, M. (2008). Prevalence of four enteropathogens in the faeces of young diarrhoeic dairy calves in Switzerland. In: Veterinary Record, vol. 163(12), pp. 362-366. ISSN 0042-4900